2 Corinthians 7:1 Having therefore these promises, dearly beloved, let us cleanse ourselves from all filthiness of the flesh and spirit, perfecting holiness in the fear of God.

The promise of God’s presence and power supporting us to this new life of holiness requires that we will rid our lives of all defilement. The defilement of sin that separates us from our Father in heaven, that grieves the Holy Spirit within us and shows our ingratitude toward our Lord Jesus Christ who saved us.

Defilement of the flesh includes all forms of physical impurity, whereas filthiness of the spirit covers one’s inward life, motives, and thoughts. [MacDonald]